If none of that helps, Please do a full clean re-install:
- move any valued save games elsewhere
- "uninstall" in Steam-Vic3
- manually delete both the Steam/SteamApps/common/Victoria3 AND Documents/Paradox Interactive/Victoria3 folders- In particular make sure there are no files or folders left under either the Steam Victoria3 or Documents Victoria3 locations, before installing again.
- re-install game in Steam, run a Steam Verify when done.
- add Victoria3.exe to the exceptions list of your antivirus app; ESPECIALLY if you have Windows Defender, add it to the Ransomware "Apps Allowed Through" list.
THEN Right click on victoria3.exe , properties, compatibility. Tick "disable fullScreen optimisations" untick every other box in that dialog, Apply and exit.
Then in the launcher Game Settings menu, select fullScreen display mode, Vsync off, cap refresh rate at 60.
THEN test with a new unmodded campaign NOT any existing one.
If those don't help:
DXDIAG is a program you run from the Windows search box on the task bar. After running it will open a window and start collecting info with a progress bar in the lower-left corner. When it completes click the 'save all information' button and save it to a file then attach that file here.
Please attach here your Documents/Paradox Interactive/Victoria3/pdx_settings.json .
From your Documents/Paradox Interactive/Victoria3/logs/ folder, attach here system.log , error.log , exceptions.txt