I've only done a few runs so far. Still newish.
Tried Europe twice, cuz I totally assumed I'd be a tech rusher.
First time I got pretty far, maybe half the tech? Then I let the dude explode the giant bomb, and the endless dust storm killed me. Combo of suffocation and suicide spiral.
Second time I got a bit farther, but towards the end of the Last War I hit a suicide spiral. Both times I had been the City Mayor, cuz build costs.
So I thought, on if suicide is killing me, I'll try the Church of the Ark, with Rocket Scientist fir the early shuttles. NAILED IT. Got the good ending of Last War, 100% terraformed, researched everything, built everything, had 5k colonists, all martianborn, all that.
So now I've been testing Paradox and Japan, cuz what I wanna try to pull off is to get my colony to be 100% bio-robots. Setting the mystery to Artificial Intelligence for the theme. No idea what that one does, but it sounded appropriate. Those havent gone well so far, lol.