At first there were no problems with the performance, but it went bad over the time. Maybe the compressed save is at fault. It's much faster, but the singleplayer game is like a lagging multiplayer one...
War leaders not changing had a strange effect, Crimea attacked Genoa, Europeans went whackfast on Ottomans+Crimea, but they win because the eastern provinces was captured by the Crimeans, the European ones revolted, and Genoa accepted peace for becoming a vassal of the Crimeans. I will see some steppe horde in the HRE soon...
One thing is that now it shows every member that might join against you in a war. But since you don't have the 60 day limit, it's still a bit unpredictable. I attacked Köln for Westfalen, because they had no allies. After some weeks, they started to make allies, and they joined into the war. After Ansbach finished her war, I called him, and joined (about a year after the start), and managed to win that war. However, Bavaria attacked right after that... That war is still ongoing, I'm just taking a pause.
Mzab was crushed by Sunni zealots. Mamluks and Ottomans both went after east Anatolia (Mamluks were first, they got Aq). Somehow Byzantium went into Bosnia. I haven't been paying attention for that area, I just noticed it at some point. Nothing really seems out of order so far.
Except I don't know what is this unrest for. It says I have 8, but what does that mean? No idea...