My Qara Koyunlu--> Persia game, 1821, with only 1 reload after I managed to get 2 tribal succession crises in 3 years and Persia defected (I still dealt with the 2, but i went after the nationalists rather than the Pretenders). But that wasn't the end of my troubles as a massive Bohemia and Muscowy decided that I looked like a tempting target at the point in time when I had completely westernized, but had not reformed my military. Of course, the fact that the steppe nomad unit group does not have any unit upgrades after land lvl 5 really forced me to use a scorched earth tactic.
Anyways, I failed to complete my main objective (completely removing Sunnis from the world and restablishing the caliphate at its peak); however, there is only one government that still has Sunni as its religion, and I consider that a victory enough.