Cusco is a good choice. I recently did a run for Sun God.
Speed is the key early, taking over as much of the nearby lands as possible. It's not easy, as the terrain is brutal, and prosecuting offensive wars while hoping to fight defensive battles is a juggling act. Bait-and-reinforce battles were common for me, and micromanaging my armies to arrive in a province a day before the enemy stack so that I get defensive status was key. Eliminating your neighbors by hook or by crook quickly is needed to build authority and get the reforms passed. You are also in a race against the European colonisation, so turning as many coastal provinces as possible is important.
In my run I was bordering a colony by the early 1500s, so there isn't much time to grab as much as you can.
Wars against colonies are now much easier than they used to be, since you can declare war without the overlord being involved. You can take huge parts of the continent in these wars.
For tech I just tried to keep up with MIL as best as I could. The tech costs are so high until you reform religion that it just isn't worth trying to keep up, and you'll get a massive tech boost once you reform so don't spend your points trying to keep up with ADM or DIP. You'll need the ADM points to buy up Stability anyway when you pass each reform. Your saved points cap will be high and may as well horde them if you can. I suggest staying Inti.
The gold provinces won't be much help until you reform. but once you do the value gets a massive boost and the economy takes off. You will become a republic, since that's what colonies are but that's easy to get out of if you want by tanking RT.
I took Expansion first, since Exploration no longer gets a second colonist. But shared discovery was painfully slow so eventually I had to take Exploration too in order to reveal South America.
Be sure you are properly prepared when you flip the switch to pass each reform. Each of these pops rebels, which are stronger and with high morale. It is essential to have full manpower in order to clear these rebels and pass the reform. If you go in unprepared you won't succeed and then it will snowball away. If you run out of manpower before you've dealt with the reform rebels you'll be in a bad spot. It's vital to win these and quickly. By necessity, your nation will be long and lean at this point, and when you enact a reform three rebel stacks will spawn, and can be anywhere within your realm, meaning it will take time to run around playing whack a mole, giving them time to siege down a number of provinces while you try to knock them out. Attacking in to this terrain is dangerous, so it's difficult to succeed while preserving your manpower.
Once you reform religion the run opens up, and now you can take on the colonial nations, build a powerful navy and scoop up the ducats by the canoe-full, while preparing for the showdown with one or more of the Europeans who will eventually have designs on your digs.
A Cusco in to Inca run is really fun, and you need to be ruthless in the early going. Full war-monger mode until you can reform religion.