Doesn't this change to CoTs essentially mean the only way a Middle Eastern nation (including the Ottomans) can get a CoT is to either take or disband the Alexandrian one (or, for added lulz, Astrakhan).
As they're all really mercantile, this is a bit of a blow to anyone who wants to pursue a peaceful economic strategy. We can't really trade as we don't have CoTs of our own and our compete chances are rubbish, and now we can't have CoTs either.
In fact, it hits any nation that's mercantile but trades through a moderately wealthy, but not very wealthy, CoT. In other words, anyone outside Western Europe.
I guess not everyone gets to trade.