My Big would be "inspired by" The Luminaries, rather than having it as a theme as such. Which is to say I don't think I could do justice to such an intricately crafted book, and that it doesn't really grab you emotionally anyway; but the setting and general gist of it is perfectly suited to a Big. Gold rush in a colony at the edge of the Earth, with smugglers and drug dealers and blackmailers and murders. I'd be going for no cultists, two wolf varieties as suggested by randakar. Otherwise very orthodox.
That is if no one jumps in. Feel free to if you're burning with a passion to GM, but I'd be pretty happy to return to it even this soon after Queen II.