(...)
- -10% local autonomy(?)
- -25% local culture conversion cost (You're essentially constructing a state-sponsored education facility in the province, perhaps it would be easier to spread language and culture through it?)
Universities would increase autonomy most likely. But the transition from Middle Ages to Rebirth to Enlightnement covers massive changes in academic life and higher education. And many universities were by all means cities within cities, with all that imply.
The Culture conversion bit makes sense, but it should be tied to a decree or something, as that was not always the case. Many fought against assimilation, some fought for it. Just as some were revolutionary and innovative, while others were pedantic and tradionalist.
Not without reason the great Doctor Paracelsus said there was more knowledge in his shoelaces than in all of Europe's schools and universities. Some scholars from diverse backgrounds and fields, going from Martin Luther to Alexander von Humbolt to Carl F. Gauss to René Descartes to Tycho Brahe to Eramus Darwin (and eventually his grandson), had a love-hate-hate-hate-hate relationship with academic life.
And do not get me started on the whole Leibniz-Newton affair.