I should probably start an AAR if I want to keep updating this, but …
After vassaling Savoy in early 1515, I DoWed Naples the same year. Unfortunately they were allied with both Austria and Hungary. Through a combination of factors – including poor AI play by France and uncharacteristically decent AI play by Austria/Hungary – this was a tough war. It ended in 1520 with my manpower trashed, Naples a vassal, Slavonia “returned” to Croatia, and a one province Styria vassal created. No bad, but I probably will need to give up the dream of a Burgundy vassal (pretty sure they will disappear in 24 years, and I need to prioritize getting Styria’s provinces “returned” before they expire).
Ferrara was annexed as well, as was Venice in 1524. 8/6 DR. Austria HATES me. Breaking the RM didn't help there (I am curia controller, so at least no stab hit).
It’s now 1524, the truce just expired with Austria. I’ll DoW with the goal of build a bigger Styria. It may not be easy, though – Austria, much weaker in and of itself, leads a personal union with much stronger Castille. Hopefully France won't play like an idiot this time.
I still don’t know how to post a proper screen shot, but here are two from 1520:
http://imageshack.com/a/img198/961/1ecc.png
http://imageshack.com/a/img835/8485/fywa.png
Edit - not going to keep posting new updates here, but will edit this for another update. Now 1548, a slow 28 years, because of two long wars with Austria (the first of which trashed my manpower again, the second of which went better), and a prolonged period of peace because I messed up and didn't leave myself with a border with Austria (or any other likely target) for about 10 years or so. But added in that time Provence, all of Styria's cores to Stryria (7 provinces), annexed 3 vassals (Venice, Croatia, Switzerland) and, belatedly and probably stupidly, created a Burgundy vassal (one province; most cores disappeared, except one additional core. But I can feed it some provinces in the vicinity I hope). I'm at 54 provinces including my vassals (now 8/8, 7 of whom are vassals. France still my ally). Wasted my colonist and Asian CB so far; discoveries haven't spread and colonial range low. Moving north with the ultimate aim of dismantling the HRE. Still hoping eventually to head for India.
Second edit - not going quite as well as I hoped - still much to learn apparently. I did win another war with Austria, but expansion is increasingly constrained by a number of factors. France turned on me - we haven't gone to war yet, but it is only a matter of time. Fortunately I am a little stronger than they are & they don't have good allies. But if they attack me when I am fighting Austria, for example, I'll be hurting. I've allied with England & am considering allying with Castille, who broke away from their PU with Austria, but they don't share a border with France. Aragon does, but they still view me as their rival.
Final edit - man, that change to AE scaling is going to make a huge difference. 1565, making very slow progress. No colonial action so far, though I tend to think that is to some extent a failure of imagination on my part. Still haven't fought France; allied to Bohemia and England. The lack of low AE cost conquest opportunities, and wanting to avoid coalitions, is slowing me to a virtual standstill. Thinking of starting something new, though I might as well get the Italy achievement first. Still and all, not bad for my second iron man.