I can contribute a bit to that Disruptor/CL vs Neutron debate:
I've begun my quest to determine the best loadouts against FEs by pitching test fleets against event-spawned FE fleets of one Titan, 30 Battlecruiser and 60 Escorts five times for each FE type. This gives me more refined results opposed to just fighting the Doom Fleet of Doom. Also, I've edited the defines to make large enough fleets possible because there apparently is no way to nullify the command limit via console.
So far I've tested mono-BB fleets starting with the F1/5-TB-2KA2P which was best in 1.8/1.9 (let's see how the notation works out - I did replace Decoders with Auxiliary Fire Controls though; I'm trying to avoid the special tech you are not guaranteed to unlock) to get a benchmark. The very first observation with those - thanks to having split the Doomfleet - is that the 1 shield plus 5 armor setup is most definitively not optimal anymore; it gets hardcountered by Materialists and Machines. I stuck with it for comparability, though.
On the weapons side, what sticks out are GB-1KA3N (any combination of Tachyon, Giga, Kinetic Artillery and Neutron Launchers, in fact) and AB-6D1H respectively AB-4CL if one should happen to find cloud lightning. The former has the highest lethality while the latter has the highest survivability.
In more detail, the siblings of the 422 rely on high damage and low firerate weapons which causes them to quite noticeably deal damage in waves. In each wave they kill a chunk of the FE fleet with downtimes in between where damage is rather lacking. As a result, the FE ships stay in combat longer and individual ships get focused fired down, preventing emergency FTL jumps, which kills up to 90% of the FE fleet before combat ends. The downside of course is that after each volley there are healthy FE ships left which inflict high casualties on the test fleet; with the armor focused defensive setup I used these range between 20% and 50% against Spiritualists, Xenophobes and Xenophiles and up to 80% against the Materialists and Machines (which then also end with the test fleet disengaging instead of the FE fleet).
Contrast this with armor and shield ignoring weapon loadouts: They deal damage more consistently, but directly to the hull; as a result FE ships have the opportunity to emergency FTL, but are also constantly debuffed from the hull damage. They kill about 70% of the FE fleet while suffering losses of around 10% against Spiritualists, Xenphobes and Xenophiles and 30% against Materialists and Machines.
I attached the concrete results as an excel file.
Now, in the test setup the FE fleets lack the buffs they have in an actual game - and there they have considerably more armor and shields while not that much more hull. As such, I expect Disruptors respectively Cloud Lightning to perform better than the 422-esque designs in an actual game. Furthermore, due to the lower amount of losses they suffer they should generate less war attrition and they're cheaper, so for now I declare armor and shield penetrating setups to be the best choice against FE if you happen to bring mono-BB-fleets. Or in other words, to get back to the Disruptor vs Neutron debate: If the enemy has enough armor and shields compared to hull, then Disruptors will outperform Neutron.
I do suspect however that BBs are not the best hull to actually wield Disruptors into combat and am going to test other hulls for now.
Edit: Tested corvette swarms and they are... eh. Corvettes are not completely useless like in 1.9, but they cannot compete with the BBs. The corvette swarms suffer the same percentage of casualties as the FE fleets and are therefore not a good choice considering war attrition. Specifically, I tested swarms of A1/2-CV-3D, A1/2-CV-1D1T and A1/2-CV-2AC1P and they performed all rather similarly. Concrete results at a later time.
I've begun my quest to determine the best loadouts against FEs by pitching test fleets against event-spawned FE fleets of one Titan, 30 Battlecruiser and 60 Escorts five times for each FE type. This gives me more refined results opposed to just fighting the Doom Fleet of Doom. Also, I've edited the defines to make large enough fleets possible because there apparently is no way to nullify the command limit via console.
So far I've tested mono-BB fleets starting with the F1/5-TB-2KA2P which was best in 1.8/1.9 (let's see how the notation works out - I did replace Decoders with Auxiliary Fire Controls though; I'm trying to avoid the special tech you are not guaranteed to unlock) to get a benchmark. The very first observation with those - thanks to having split the Doomfleet - is that the 1 shield plus 5 armor setup is most definitively not optimal anymore; it gets hardcountered by Materialists and Machines. I stuck with it for comparability, though.
On the weapons side, what sticks out are GB-1KA3N (any combination of Tachyon, Giga, Kinetic Artillery and Neutron Launchers, in fact) and AB-6D1H respectively AB-4CL if one should happen to find cloud lightning. The former has the highest lethality while the latter has the highest survivability.
In more detail, the siblings of the 422 rely on high damage and low firerate weapons which causes them to quite noticeably deal damage in waves. In each wave they kill a chunk of the FE fleet with downtimes in between where damage is rather lacking. As a result, the FE ships stay in combat longer and individual ships get focused fired down, preventing emergency FTL jumps, which kills up to 90% of the FE fleet before combat ends. The downside of course is that after each volley there are healthy FE ships left which inflict high casualties on the test fleet; with the armor focused defensive setup I used these range between 20% and 50% against Spiritualists, Xenophobes and Xenophiles and up to 80% against the Materialists and Machines (which then also end with the test fleet disengaging instead of the FE fleet).
Contrast this with armor and shield ignoring weapon loadouts: They deal damage more consistently, but directly to the hull; as a result FE ships have the opportunity to emergency FTL, but are also constantly debuffed from the hull damage. They kill about 70% of the FE fleet while suffering losses of around 10% against Spiritualists, Xenphobes and Xenophiles and 30% against Materialists and Machines.
I attached the concrete results as an excel file.
Now, in the test setup the FE fleets lack the buffs they have in an actual game - and there they have considerably more armor and shields while not that much more hull. As such, I expect Disruptors respectively Cloud Lightning to perform better than the 422-esque designs in an actual game. Furthermore, due to the lower amount of losses they suffer they should generate less war attrition and they're cheaper, so for now I declare armor and shield penetrating setups to be the best choice against FE if you happen to bring mono-BB-fleets. Or in other words, to get back to the Disruptor vs Neutron debate: If the enemy has enough armor and shields compared to hull, then Disruptors will outperform Neutron.
I do suspect however that BBs are not the best hull to actually wield Disruptors into combat and am going to test other hulls for now.
Edit: Tested corvette swarms and they are... eh. Corvettes are not completely useless like in 1.9, but they cannot compete with the BBs. The corvette swarms suffer the same percentage of casualties as the FE fleets and are therefore not a good choice considering war attrition. Specifically, I tested swarms of A1/2-CV-3D, A1/2-CV-1D1T and A1/2-CV-2AC1P and they performed all rather similarly. Concrete results at a later time.
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