Institution spread is a % modifier, it is useless unless you are already getting spread in the provinces in question. Usually, you just enable that one in a couple border states to be able to embrace sooner, then turn it back off. There's not much point for using it on institutions you will get within 5-10 years.
+200% cost tend to overwhelm any purely economic benefit, so edicts are inherently pushed towards temporary use. I mentioned defensive earlier in the thread, but development, de jure law, religious conversion, and advancement all see temporary use game to game too.
It is difficult to imagine many normal cases where a small amount of ticking autonomy reduction, trade power, or manpower is worth the added costs. Maybe you can mass the trade power one for a year just to hit an estate mission, then drop it again.
De jure law is interesting while it lasts. If you annex same-religion territory, you can often lower autonomy, wait until rebels are nearly 100%, then turn it on for a year to slap them back to 0%. Disable and repeat later until the 30 years pass.