Here is a list of common errors found in output_log.txt.
No idea what impact they have on game play. Sure, I could suppose that one or another could have an impact but what type of impact, who knows. Without someone with internal knowledge of the program structure it's more or less useless to make speculations about the impact of error messages.
Mods
Fallback handler could not load library C:/Program Files (x86)/Steam/steamapps/common/Cities_Skylines/Cities_Data/Mono/data-000000002070B760.dll
Assembly HardMode0, Version=0.0.0.0, Culture=neutral, PublicKeyToken=null loaded. [Mods - Internal]
Fallback handler could not load library C:/Program Files (x86)/Steam/steamapps/common/Cities_Skylines/Cities_Data/Mono/data-00000000208F2940.dll
Assembly AdvancedVehicleOptions, Version=1.0.5629.25264, Culture=neutral, PublicKeyToken=null loaded. [Mods - Internal]
Assembly resolution failure. No assembly named '2.5.29.16' was found. [Serialization]
Filename: C:/buildslave/unity/build/artifacts/generated/common/runtime/UnityEngineDebug.gen.cpp Line: 56)
m_SteamUGCRequestMap error: 9
[Steam, Native - Internal]
(Filename: C:/buildslave/unity/build/artifacts/generated/common/runtime/UnityEngineDebug.gen.cpp Line: 56)
m_SteamUGCRequestMap error: 15
[Steam, Native - Internal]
Assets
LOD missing: 407784061.Shopping Carts_Data [Core]
Unknown prefab: palmplant01 [Serialization]
No props placed: 407779177.Government Office_Data [Core]
No base generated: 409887119.Log House_Data [Core]
Unsupported format [Importers, Native - Internal]
System.FormatException: Loading custom asset failed:['Japanese shop 2 ' [CustomAssetMetaData, 6a819d2deb7ab433aa60abb6f82ab5cd, in package ''410399351' [C:\Program Files (x86)\Steam\steamapps\workshop\content\255710\410399351\Japanese shop 2 .crp]' (4716899, 2048)]]
Invalid DDS Image: failed to load [Modding]
d3d11: failed to create staging 2D texture w=6 h=6 d3dfmt=71 [80070057]
d3d11: failed to create staging 2D texture w=3 h=3 d3dfmt=71 [80070057]
XYS size doesn't match diffuse: 417001466.Shack 4 - Fallout 3/New Vegas_Data [Core]
Unsupported type for deserialization: [SpawnPoint]
Diffuse is DXT5: 420568834.OMP_Data [Core]
Assembly resolution failure. No assembly named 'NohealforuSimulationOverhaul, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null' was found. [Serialization]
Assembly resolution failure. No assembly named '1.2.840.113533.7.65.0' was found. [Serialization]
Unkown type detected. Attempting to resolve from 'NohealforuSimulationOverhaul.NohealforuCommercialBuildingAI, NohealforuSimulationOverhaul, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null' to 'NohealforuSimulationOverhaul.NohealforuCommercialBuildingAI, NohealforuSimulationOverhaul, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null' [Packer - Internal]
Unexpected type 'NohealforuSimulationOverhaul.NohealforuCommercialBuildingAI, NohealforuSimulationOverhaul, Version=1.0.0.0, Culture=neutral, PublicKeyToken=null' detected. No resolver handled this type. Skipping -1 bytes. [Packer - Internal]
Warning: texture atlas shader ** not found.
Unexpected type '' detected. No resolver handled this type. Skipping -1 bytes. [Packer - Internal]
Unkown type detected. Attempting to resolve from '' to '' [Packer - Internal]
Unexpected type '' detected. No resolver handled this type. Skipping -1 bytes. [Packer - Internal]
System.IO.InvalidDataException: Loading custom asset failed:['Power Relay Station' [CustomAssetMetaData, 3f8718d0bb1e142e9da729cb1397f9cb, in package ''438070008' [C:\Program Files (x86)\Steam\steamapps\workshop\content\255710\438070008\Power Relay Station.crp]' (8993965, 2048)]]
Unknown type to deserialize [Modding]
System.IO.EndOfStreamException: Loading custom asset failed:['Torre St Pere MÃ rtir' [CustomAssetMetaData, ec7feeb32b1810ec0b9941a2c46eedc6, in package ''442722094' [C:\Program Files (x86)\Steam\steamapps\workshop\content\255710\442722094\Torre St Pere MÃ rtir.crp]' (9585844, 2048)]]
Failed to read past end of stream. [Modding]
LOD has no base: 424262808.Deep Space Satellite Dish_Data [Core]
LOD vertex count high (1863 > 560): 410598427.Bell Tower of Florence_Data [Core]
Mesh.vertices is too large. A mesh may not have more than 65000 vertices.
Mesh.normals is out of bounds. The supplied array needs to be the same size as the Mesh.vertices array.
Mesh.tangents is out of bounds. The supplied array needs to be the same size as the Mesh.vertices array.
Mesh.uv is out of bounds. The supplied array needs to be the same size as the Mesh.vertices array.
Mesh.colors is out of bounds. The supplied array needs to be the same size as the Mesh.vertices array.
Failed setting triangles. Some indices are referencing out of bounds vertices. IndexCount: 158400, VertexCount: 0
There is no building that would upgrade to: 406642442.Landhandel_Data [Core]
Building cannot upgrade to next level: 416882049.Movie Theater_Data [Core]
NullReferenceException: Object reference not set to an instance of an object
at CompassMod.CompassMod_GUI.ShowImg () [0x00000] in <filename unknown>:0
at CompassMod.CompassMod_GUI.OnGUI () [0x00000] in <filename unknown>:0
Ignoring invalid matrix assinged to GUI.matrix - the matrix needs to be invertible. Did you scale by 0 on Z-axis?
Error with MAIN_CATEGORY[Default]:0: The id was not found in the localization files. [Localization - Internal]