Now ive never run this game on PC, ive been xbl for years now
But i used to rag the hell out of sub par hardware, and saved a fortune not buying latest stuff
I can give you pointers
1st off, its probably your PC being "weak"
Skylines is RAM heavy, it likes lots of it, it likes it faster.
An SSD will alieviate some off those issues, a small one just for windows and the "swapfile" is ideal and prices of these are sensible
You are most likely struggling with "through put". Thats why the 1st suggestion above and from me is your RAM
Other things such as bus speeds, (the mobo ability to move sh1t) from a to b.
Maybe also CPU, at higher pops this can also be an issue. Mods like Traffic Manager, (with sim +ed) will murder CPU at higher pops
Simply put, you have a bottleneck
Laptops almost invariably have less capable mobos, they dont give ram its full speed, and then dont get full fat 100w CPUs
Do a test,
Stare at water/blank ground.
Run on fast forward,
If it still slows then its weak cpu/bus, if not then its defo RAM/Bus
NB, its always /Bus cause its always a possibility.