It might be a really strange idea, but at the moment, if you want to play efficiently (and the game sort of forces you to at the start of the game), you're more or less forced to start with building grids to get things going. As far as I know, grids are the most efficient way to build, transport wise, building wise, money wise and space wise. Would it perhaps be an idea to find ways to reward people that do not stick to grid building to encourage people to become a bit more creative? Maybe add some modifiers for traffic, land value etc. Maybe have areas that are on bending roads spawn different buildings that are more efficient in a way.