2.2.1 is now out, so probably worth doing a full clean re-install:
- move any valued save games elsewhere
- "delete local content" in Steam-CK2
- manually delete all files and folders left under Steam/CK2 AND Documents/Paradox/CK2
- re-install game in Steam, run a Steam Verify when done.
Then edit that settings.txt to say refreshRate=60
That aside I see no real problems in those files. You say the crashes are random; is there nothing linking them? Do they only happen after playing for a while, or on any particular action or event? After such a crash, can you restart the game immediately OK? Or do you need to reboot, or to wait a while?
Do they happen in a newly started game under 2.2.1, or only in games started under older patches?