Played till 1520.
It is too easy. Manpower not a problem. Money not a problem.
Till 1515 all American natives incorporated, in all COTs 5 merchants or monopolies. Monthly income close to 500 d. BB and stability don't hurt merchant presence at all as long as I don't force minimal monopoly (6 merchants). At least not against AI. In the richest COTs I compete all.
Send an COT snaching expedition: 3x20 k army. Took Shanghai and some more Chinese provinces, Annexed Malacca (who cares about -5 stab - break truce on the day it is signed

), took Ganges and Howrah from Bengal. Got tired of it, with 40 k still with me (some minor recruitment along the way).
A COT popped up in Spanish Argentina. An outrage! Send those 40 k to Spain, burned her TPs, assaulted medium fort of Madrid, assaulted my way to Andalusia and almost succeeded. Not wantng to bother with it any more, took Spanish American colonies for peace. America is all mine except 3 English colonies/TPs in the north. Thery are next target as soon as stab reaches -2.
Did I mentioned rebells? Not a problem, because most of those provinces are low populated. BB wars? None dares to DOW, although BB=100/43.
What am I doing with money? Generally not caring at all, but when there is 20 k in the treasury I build 10 manufacturies. Refineries, FAAs, infrastructure. And I try to gave all provinces max developped, naturally, but it's hard when they multiple so fast

.
TOO EASY.
Perhaps better to have Aliens in Oceania, so that they actually have to develop colonies for manpower.
The only bright spot is naval combat really is much more a risk than land combat. So, 10 warship alien fleet can lose 5 warships while fighting French 15 warships and 5 galleys.