Another person here who felt obliged to make an account in response to this news. I'm kinda in the odd place in that I am very much a fan of the World of Darkness, but I'm not really a pen and paper roleplayer (I like the setting, but pen and paper roleplaying just isn't my thing), so the news that WoD is going to be expanding out from being a purely pen and paper property is great. Of course, I'm much more a fan of the New WoD than the Old WoD, so...I guess we'll see how that goes.
That said, I have been thinking about how the NWoD could work in terms of PC games, especially considering the fact that Paradox is almost certainly going to want to make heavy use of the OWoD. So it becomes a question of how it could work for Paradox to make use of both of them simultaneously. This is what's come to mind with regards to how to do that.
So I figure the key to using both would be to make sure that the two settings are clearly differentiated in the minds of the playerbase, so that they don't get confused about why, for instance, the different vampire clans keep changing from one game to the next. I'd imagine that if Paradox is concerned about this kind of brand confusion, a simple place to start would be the names of the settings, as them having the same name would probably be cause for confusion with anyone who isn't already invested in one of the settings. Personally, if they felt like changing the name of the NWoD (because let's be honest, they aren't going to be changing the name of the OWoD) would make it a more usable property, I'd consider that a reasonable price to pay.
Beyond that, if they want to differentiate the settings in the minds of gamers, I would say that the obvious next step would be to use each setting for very distinct and separate types of games. In the case of RPGs, use each setting with different RPG sub-genres, ones that play to each of the settings' perceived strengths.
So for the OWoD, I would go for what I'll call Bioware-style RPGs--ones with a heavy focus on story, writing, and creating interesting characters, and generally leveraging the hell out of the accumulated lore that's built up in the setting.
And for the NWoD, aim for Bethesda-style RPGs--where the focus is less on story and more on setting, creating a big open world sandbox with cool stuff in it, where the player gets the experience of playing a vampire (or werewolf, or mage) in the big city.
Sure, the New and Old WoDs are two settings built on similar foundations, so even with this there might still be some initial confusion, but if Paradox is in for the long haul, I'd be willing to bet that the confusion would soon subside, and people would understand what each setting brings, and which ones they're interested in.