As many have noted, I'll worry about the Ottomans when the AI started to become OP. The only thing that I'm worried about is that after 1650, the game doesn't really have a "balance of power' mechanic where the major powers attempt to keep each other in check. Sure, they ally each other's rivals, but usually after a certain point one of the colonial powers (Spain, Portugal, Britian, or France) has gained enough power to just overrun the others. I'd be more worried about making sure Spain and France are properly nerfed so they don't unstoppable by the end game.
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