Papal States
Hyz,
I don't think the Pope suffers from anything that can't be solved in-game. I think you can exploit your diplomatic situation better than you have up until now. Most of the Catholic nations acknowledge that Genoa and Venice are within your zone of control. I bet Spain, Portugal, and Austria would even provide military or financial support in your conquering/annexing Genoa, and France would probably bend to international pressure to allow it.
Does Venice or Genoa still own islands? If so, I bet you could convince Austria, Spain, Portugal, or even the Ottomans (actually I think even Poland's navy is large enough to manage this) to conquer the islands so you can annex Venice.
As for cash, all of the Catholics should be helping out a bit (yeah, I've been naughty too). Even though you're a CRT behind, your manpower is substantial enough for you to be a force to be reckoned with (with funding..ahem Portugal and Spain). The Iberians donations to you give you the beginnings of a colonial empire, that should bring in a small amount of additional cash.
And while its true that Brandenberg is marginally stronger, its diplomatic situation is far, far worse. It borders three major nations, two of which don't want to see any parts of the HRE annexed and don't like Brandenberg's Protestantness. You'll also have a major struggle in winning back Prussia, which you need for the Prussian inheritance to fire. You may end up stuck as Brandenberg throughout the 1700s. No leaders, no great monarchs, no great events. Ick. Brandenberg's no easier than the Pope.
I suggest you stick with it in Italy. Speak up more, and I'm sure the others will lend a hand. Don't just complain, tell us what you want. You want me to stop blathering? Right then,
Edit: I don't think editing is a good solution for any of this. All of the problems here can be solved in game. Inflation and BB can be lowered over time, relations with Venice/Genoa can be improved with donated cash, and so on.