I'm playing 2.1.1, I can't remember if I started in 2.1.0 or 2.1.1 and I play with retinues. I haven't noticed anything that would be the cause of the crash, but when it happens I can reload the last autosave (set to every six months) and continue just fine for a while.
You could disable patrician retinues if that's the problem (like Meneth did for Project Balance) as a temporary fix. Paradox will hopefully fix it in the next patch.
Well maybe we should have disabled them completely but it's kind of harsh to force the player not to use something the game is now designed to work with. Maybe we've put a bit too much trust in PI's support, but I think it's a first with them to knowingly leave the game with a major CTD bug for more than a month. Warning and informing people about that is kinda impossible right now with the single thread, plus repeating it again and again also contributes to the flood of information in here. Kind of a vicious circle if you ask me.
Playing without retinues, I have completely two 2.1.1 test games (not much interaction with the AI but that shouldn't change much to that specific problem) without a single CTD. So I'm more worried about CTDs occuring with the last version and disabled retinues.