I was playing France when Spain invaded to take Toulouse, they completely annihilated me, crushed my armies. They then occupied near half of my holdings. I thin went to make peace but they wouldn't accept anything. I offered as much money as possible, all of the provinces they had cores and that they wanted and then i offered to release most of the vassals that i had just diplo annexed. they still refused. the war score i was offering was near 400. yet they still refuse!!!
The warscore doesnt matter. hover you mouse around the "X" of your offer.
If you got less then -1000 it says that there is something you give them that they dont want (like release of their enemy, or cancel of treatment that they want to keep).
if it so, clear your offer and let them only things with a green hand on them, try different stuff.
After this, when you got more resanable offer, they will luckly accept.
If they dont (if the offer is still in a minus, but not of -1000) you can try wait till their war exhstion will rise.
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I ware in much worst situation: War with England, Astria, Spain, Aragon, Portugal while my only ally is one province vassel.
... In "Ironman mode".
luckly only had to release only 2 nations.