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Strat bombers. Select the unit itself, down the bottom (where the brigade button is) there should be a nuke symbol with a green +. Click it and you load yourself a nuke onto said bomber.
I think at least 5 reactors are needed. Not 100% sure though, been a while since I've used them.
A little nuke icon appears somewhere near the national manpower information. Putting the mouse over that icon tells when the next nuke should be ready.