I also have the same issue which I first encountered yesterday. Ironman mode was disabled. I could not start any new Ironman game nor load any Ironman save. The Ironman checkbox and the Play button were greyed out with "Ironman mode needs EU4 to be unmodified and validated." It did not seem to be a steam cloud problem since I could still see my games saved to steam cloud. I have no mods installed and have all the current DLCs up to CoP.
Initially I did a clean reinstall and that solved it for me. However, when I loaded up the game today, the issue came up again. Really don't understand why this happened, as I had no problems playing a few days ago.
Issue still pending. I went and did another clean reinstall, which temporarily solved the issue and was able to play Ironman mode. However, once I rebooted my computer, the "Ironman mode needs EU4 to be unmodified and validated." problem resurfaced. Hope someone can shed some light on this mystery, as I don't want to reinstall the game everytime I want to play Ironman mode.