In order to save anyone else the grief, here's how to fix eu2 on windows 10. Note in this situation, the app runs, but can not load any games, crashing when attempted.
Run "regedit",
I´ve found this "folder" "HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers" with the key C:\Program Files (x86)\Strategy First\Europa Universalis 2\EU2.exe
Change value field to ''$ DWM8And16BitMitigation WINXPSP3 Layer_ForceDirectDrawEmulation'', no quotes.
Run "regedit",
I´ve found this "folder" "HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers" with the key C:\Program Files (x86)\Strategy First\Europa Universalis 2\EU2.exe
Change value field to ''$ DWM8And16BitMitigation WINXPSP3 Layer_ForceDirectDrawEmulation'', no quotes.