Ehh. Do you mean any game in which a player is involved? Or just running the AI from 1441 to 1821? Because players are magnitudes of degrees better than the AI at increasing income (basically getting 20+ merchants and putting them to use while conquering valuable tradegood areas etc).
Generally speaking, EU4 finances are very different from real life finances. Any strategy game -- even grand strategy games -- kinda abstracts monetary systems in ways that still make for enjoyable gameplay. Even the most successful and expansive nations had periods where they struggled fiscally, going into debt and turmoil for whatever reasons (plagues, volcanic eruptions, earthquakes, having a bad/unlucky battle that essentially demolishes your entire professional army, etc). 'Disasters' are very timid compared to real life, and recovery is quick and smooth.
So. That was a bit of a tangent, but the global GDP in a game of EU4 I'd guess is increased by something like 800-1000%? I have no data, just a gut feeling from me. It'd be easy to just open up a spectator game and add up every nation's income at the start date and then let the game roll until the end date and check again.