Ye, the best way to destabilise Ming is to fight them asymmetrically after the Age of Discovery. My Phillipines campaign caused a superb Mingsplosion when I launched a naval blockade and took enough money for them to go into debt. Consider-
-Checking Ming's naval stats in the ledger. If you can beat them navally, a naval victory is very dangerous to Ming! One, they'll try to build their ships back up to fight you, which is a very significant economic cost- they build boats, you steal or sink them, they build more boats. Using transport ships and Marines is an excellent way to buff this strategy- if their main fleet lands in an unfortified province, or they build a ship in an unfortified province, you can send in the marines and occupy the land to force them into combat. Blockades also add War Score, War Exhaustion and Devastation, all of which help with beating them and their Mandate down.
-Running a defensive strategy rather hyperfocusing on trying to rush them. Some of Ming's biggest strengths are defensive- national ideas with fort maintenance, garrison size and fort defense, possible attrition from the Great Wall of China monument, plus any relevant ideas they take- so you're going to be at a disadvantage sieging down their forts. Instead, a wall of forts can make them split up. Find provinces near your border that you'll want to fight in (plains with minimal supply limit make sense for a horde), build the max fort level and ramparts, place a Defence Edict on the state, and- if you can afford to be frugal with government capacity and admin power- expand your infrastructure if it's above 15 development in order to maximise your Defensiveness. The longer it takes for them to siege you, the better- flank to isolated siege stacks' escape routes to crush them, then return behind your wall of forts (two lines should usually be enough) and find the next-best enemy position to attack. In the meantime, the Ramparts' bonus attrition (as well as any other attrition sources, like supply limits, or Defensive Ideas) will be steadily ratcheting up Ming's War Exhaustion.
If you manage to defeat Ming on land, excellent! If not, then as long as you're not completely outmatched, you should be able to grind Ming down until they'll give you lots of cash in return for buggering off. If you've done it right, then they've wasted a whole bunch of money on boats or attrition, they've gained a lot of war exhaustion from blockades and attrition, and the additional cost of giving you lots of money will push them over into debt. Then, the combination of War Exhaustion and debt (plus a small amount of Devastation) should hurt them enough for a nice, juicy Crisis of the Ming Dynasty that results in the total detonation of Ming China!
