Venice
Will try to recreate what i did with my first and best Austria->HRE game some time ago: First establish a powerful base in europe, then crusade and conquer the middle east, then take the route to india and ultimately australia. From there even farther east to the new random new world.
A colonizing spree to the new world, just going east instead of west. Which means, in america, a colonization coming from the west. Instead of east. Okay this gets confusing.
Downfall of the venetian Trade Empire due to the rise of western new world trade routes? We'll see about that Castile! I'll make my own traderoute! With Blackjack and Hookers!