So I was thinking about how Crusader Kings 2 had Reapers Due come out and represents different epidemics during that timeline, but what about during the EU4 timeline? There are certain events such as a flu outbreak, but I was thinking about actual epidemics that occurred. What do you think if there were random events added that represented epidemics that have a negative effect on your sailors and manpower? Or if it occurs in a colony it could take away a certain amount of settlers? It would add some historical accuracy. Link below to timeline of epidemics.
https://en.wikipedia.org/wiki/List_of_epidemics
https://en.wikipedia.org/wiki/List_of_epidemics