Well, historically speaking, they should be rather useless to play.
One exception could be a game start event that changes the nature of the American Indians. This may change the nature of the game completely mind you, but what if there was a real slim chance that the Amerindians were a far more advanced people. They would still need to be isloationist so as to allow the normal historical progress in Europe to game start, but what if they were at the European level when they are discovered, and had realistic chances to advance. It would really strike a little realism into the exploration and discovery period since you won't be compleyely sure until you get there what you'll find. Hell, you could even go so far as to have a chance that the Amerindians "discover" europe.
I'm not advocating this completely, but it would be a nice touch.
One exception could be a game start event that changes the nature of the American Indians. This may change the nature of the game completely mind you, but what if there was a real slim chance that the Amerindians were a far more advanced people. They would still need to be isloationist so as to allow the normal historical progress in Europe to game start, but what if they were at the European level when they are discovered, and had realistic chances to advance. It would really strike a little realism into the exploration and discovery period since you won't be compleyely sure until you get there what you'll find. Hell, you could even go so far as to have a chance that the Amerindians "discover" europe.
I'm not advocating this completely, but it would be a nice touch.