So, after preferring inflation off for most of my EU3 games up until now, I'm playing with it on.
I have a current game going with Milan and I, honestly, feel that it's easier if anything with inflation on. It was something of a challenge at first to fund my armies, but after 1420 or so it was no sweat. France and Castille have descended into constant bankruptcies, almost everyone save for me has >15inflation, and no one has bothered to DoW me more than once or twice the whole game(I've reached 1500), due to economic troubles I suspect.
It's a slightly more interesting game, though, I'll give it that. It's kind of fun to see great empires crumble due to being unable to hold their finances together.
I begin to see the value of having Lucky Nations on now, I have the strongest economy in the world and that will only get more so as I get more cores and start colonizing, whereas I foresee most of the other powers just getting weaker.