Playing as the Ottomans currently. I annexed all of the smaller nations to my east, as I had cores on them, then I allied Crimea, who blobbed a load in this game, so far. I conquered the occasional small nation to my north and west in Europe, but, suddenly, Serbia annexes Wallachia, Bosnia, Ragusa, Montenegro, Moldavia, and a lot of other small nations in that area. I'm stuck in a really odd position because the Mamluks have almost all of Arabia and, though I did end up annexing Serbia (they got into a lot of wars that they couldn't handle, so I joined in on the fun), there's still a super-Hungary to my north, and the Mamluks, for whatever reason, had half the size of my army, though they had a lot of eastern Africa and, as stated, Arabia. I managed to get a strip of territory down the Mamluks' coast, including Judea. A few years before the war with the Mamluks, I happened upon a very lucky personal union with (only had a royal marriage). Crimea is about my size (well, province-wise, only half), so I'm sitting with a lot of territory. Only real issue is that I am behind a lot of techs in administrative because I have to core and change the culture of a lot of provinces at all times because I'm going for at least a conquest of Europe. I'm keeping up in all of the other techs, though. I currently have the second best army and one of the top navies (maybe the best, not sure). Pretty good so far.
Edits: Surprisingly, aggressive expansion isn't actually all that bad. I'm much more powerful than a lot of nations at the moment, I'm able to stomp all rebellions, and when I get the aggressive expansion penalty, it only really affects the nations that I don't care about. Otherwise, the ones that I do care about already love me. I've, indeed, run across a few coalitions, but they seem to never honor the coalition alliance (very odd) or leave the coalitions, so they aren't really issues.