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Okay, may have a few problems here.
Let's rename the AVI folder to start and eliminate that one.

Now what publisher version of the game do you have?
Where did you Download the 1.01 patch from?
 
Strategy First. I DL the patch from their Website.

Ok will rename AVI.

Since Autosave takes so long I set it to: NO Autosave.

Then I started to have more CTD's. Was thinking it was related to this but now they seem to be random. I had one more last night, and had to restart the game because I progressed too far and made too many changes.

Will let you know if I can track it down.
 
If you are having problems the auto save is worth it.

Let me know how it goes.