If you wish to deliver your colonial trade home, you must do so through a primary node. Sevilla, Bordeaux, London, or Lubeck. This will requir conquest. London or lubeck are arguably the easiest to take control of. London is protected by a powerful navy, If that navy can be over come, Englands land forces are an easy target. Lubeck is controled by many small states, some of which can Field dangerous armies (Brandenburg). But the split up into many smaller states makes it the easier of the 2 choices. However going through the north will exclude other possibilities unless you can also at the same time, dominate Ivory coast and the Carribean, no easy task against the early colonizers in Iberia.
Hence my usual Amtwerp game does not rely on colonization at all, but conquest and foot holds in all the primary nodes. Although france is a hard nut to crack, Normandy and Brittany are not. North Africa can be an easy way to cut into and rob Sevilla. The benefits of this tactic is, having a more central base of power, as apposed to far flung weakly held reagions of a very spread out empire, I can keep all my power in Europe and let the other nations bring the trade to me. My cut wont be 100%, but that's the price you pay for greater military supremacy where it matters most, in Europe.
Holland is my capital, and All nodes feed some money towards it, even though I have few colonies of my own. When war comes my trade fleets provide overlapping patrol zones and can quickly be pulled together into one massive fleet. Wheras spain or england may have there fleet as far away as India. Until recently with the conquest of mexico (for the gold) and the colonization of canada I required no armies anywhere else in the world.
Edit; sorry if the image isnt loading, Image shack is having issues lately.