It might be, but we'll need your output log - or player log, depending on your OS - to know what's the actual issue. Also, if a crash report was generated, attach it too.
You can find your output log in:
- Windows: ...\Steam\steamapps\common\Cities_Skylines\Cities_Data\output_log.txt
- MacOS: ~/Library/Logs/Unity/Player.log
- Linux: ~/.config/unity3d/Colossal Order/Cities: Skylines/Player.log