If I'm playing a minor, I'll usually run the whole gamut....as Lorraine, for example, I'll invariably start with an alliance with France, grow at Spain's expense, then buddy up with Spain, leave the French alliance, and grow at France's expense, then later still, form up my own alliance with German minors to peacefully annex later, and possibly inviting some of the middling powers into the mix (ie - if Austria gets pasted and stuck as sort of a second rate power, or if Denmark gets pegged by Sweden, I'll add them to my collection too).
-=Vel=-