You don't need an extra district at the start of the game since your planets won't be full at that point ,taking it first gives you no benefit.Nor do you need to remove all blockers early it even less urgent in 2,2 than it was in 1.9 and 2.0.
Not really you didn't need to clear blockers until you actually needed that tile.A tile was only usefull if you had a pop to work on it .There was no point in clearing them all at the start and blocker techs are some of the cheapest in the game.Energy at the beginning was so plentifull that there was no reason to not spend it and after a certain point of the game the perk had no use to due the massive income and the abitly to teraform.
Imperial Prerogative or Technological Ascendancy would actually give you a real benefit since the tech research speed allowed you to get every tech faster while IP would allow you to keep more planets outside of sectors which pre 2.2 gave you more minerals and energy from your planets.You actually gained mienrals and energy that way.
Both are still my two first picks in 2.2.
Well Mastery of Nature when it was first introduced gave you all the clear blocker techs,
and made clearing blockers free. Which was simply amazing. Then they tweaked it to just reduce the cost by 50%, but you still got the techs. Then they added Land Clearance back in 2.0 but no longer gave the techs, and now they made land clearance give more districts, but reduce the discount on blocker clearing to 33%. MoN has gotten the most tweaks out of any of the ascension perks. It is still useful, but the days of superpowered utility are gone. *sigh*
On topic, Tech Acsendency is a solid pick, as is Interstellar Dominion. I wouldn't bother with Executive Vigor as your first, or Nihilistic Acquisition, mainly because you probably won't get any real use out of it until you get to picking your second perk anyway. Pick something that is both immediately useful, and remains so for the rest of the game.