I just began an Attempt for a Castilian World Conquest + True Faith Run.
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What would you suggest to do in the very beginning with Portugal?
Try to destroy/vasalize them asap or
use them as an ally to win against Morocco+Granada+Tlemcen more quickly?
(in the long run most likely Castile should vasalize Portugal and then let them colonize, right.
But short term in the very beginning?)
You only want the trade centers, let them live until much later when you can steal entire colonial nations by fully annexing
Aim for a war with aragon to get one province on the venetian sea from naples, and a province on sardinia area to cover all the genoan coast. You need these to be able to conquer excommunicated italian provinces After that leave them alone since they should be yours soon.
Ally the pope and make sure they do not ally your rivals, hope you get a chance for excommunication of your rivals.
Aim to get all the trade centers on the carbbean, then get the trade centers/provinces next to them on Ivory coast, then declare war on the africans to get the remaining trade centers. Only get trade company provinces, you dont need the rest.
Build your trade company way all the way to china, in europe vassalize somebody (I vassalize granada since I go early, but portugal would be fine I guess if you wait for explo, best would be an early aragon PU) and grab the entire berber coast and work towards your extra missionaries on mecca and jerusalem. This will make some colonists faster, as they travel by land if the land is yours.
On europe, try to eat england or france, pick your poison, if you leave france you have an event that will give you a habsburg king, which you can use to get austria+hungary and possibly the comonwealth