Well, now continuing my Zapotec campaign made me crap myself. Heck, as not-Aztecs I've already got a steeper climb ahead of me (because A: I don't the starting manpower and gold rich provinces the Aztecs start with, nor their free super leader than can practically solo the rest of Mesoamerica on his own, and B: at some point I'm going to have to take on the Aztecs and their rich, easily defensible mountain provinces), part of me is even nervous I may not be able to unite all of the region before Europeans arrive. 1460 now and I've taken out the Mixtec and Itza, while the Tatonac's are now my subjugated vassals. Still, that's nearly a century away from where you were when this happened, and I absolutely plan to take Exploration first and try to reach out to Europeans elsewhere in the Americas (Cuba, most like).
And I figure that's far more important to long term survival and success than overrunning ever single one of my Mesoamerican peers.
Tough break, OP, but survival in the Americas has always been dependent on Westernizing ASAP. RPing can be fun, but you still need to work towards survival first and foremost. Personally, I'm curious to how the AoW changes effect a long term play-through in the Americas. Back before CoP I had one with the Iroquois, and it became damn near tedious as I steamrolled through all the colonizers on the way to a super easy painting of the entire North American continent and down into Colombia. I think it'd be much more exciting if it required a wee bit of effort post-Westernization for me to accomplish my goal of a Zapotec empire stretching from Central America up through the American Southwest and on to the Pacific Northwest.
Guess we'll see. It'll probably just end in a rage quit after the OP's first post happens to me.