Look what happened when Sid Meier tried to branch off into Space with the Civilization series, it was not very good and the Civilization 5 was still superior.
When Sid Meier branched off into space he created Alpha Centauri. One of the best Sid Meier games to date and a cult classic. The second attempt was a failure, true, but your post is at the moment saying that Alpha Centauri was "not very good".
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