Interstellar Dominion: 25 (+1)
Technological Ascendancy: 4
Voidborne: 10
Master Builders: 10
Galactic Wonders: 13(-2)
Synthetic Ascension (The Flesh is Weak + Synthetic Evolution): 14
Psionic Ascension (Mind over Matter + Transcendence): 11
Insterstellar dominion for all the reasons already cited. Snowballing early game is much more important than getting late game bonuses
Down voted GW for that reason. I have yet to have a game where I fully used it, as I usually have better ways to spent minerals. Also building one at a time makes them take too much time
Flesh is weak is still better, aspecialy with survivor spiecies, because it allows you to get 100% habitability on all planets. It allows for much more snowballing, because it creates actual economic strength that allows you to expand, rather than giving you opportunity to expand more, assuming you have a fleet to support this expansion at all, and assuming you have minerals to do it.
Minerals, early one are much more of a bottleneck than influence, mid-game it becomes your fleet power, and thus technology is more relevant for this reason - you want to build starbases and colonize planets you already own.
Expanding fast isn't realy that great, if your economy doesn't allow it. You should realize, that if you expand too fast, you will end up having too little energy, and too little minerals to support your expansion, meaning that you will be unable to protect your territory from pirates and enemies.
EDIT: BTW. Mind over matter causes the same that Flesh is weak does, giving your main spiecies tomb world preference, however it doesn't give you +20% habitability for all planets, so it isn't as good - but still good enough.
EDIT2: Althou, Mind over matter, doesn't require special project for your spiecies, so you get latent psionic for free.