Instutions works as a treat tho, I got the renaissance easily, but playing as Russia colonialism doesnt find you until the 1600s......
You should not wait for instutions to reach you all the time...You should build a farmland to sky!
Renaissance = Wait if are at hre or develop 2-3 province till they reach 20 dev in europe.(For muscowy Novgorod and Muscow is enough to embrace it cheaply after 1 tile spread arround.)
Colonialsm = Wait if you are in hre/france/iberia or pick colonialism and unlock only 1 idea and try to start in your empire. Then dump the idea.(You can see at least 1 post a day at reddit about colonialism start in africa or east asia)
Printing press = Wait if you are in hre or border large protestand/reformed.
Global Trade = Depends on CoT around you.
Manufactories = Just build manufactories with space in between. Don't Build manufactories between 2 neighboor province unless super rich.
Enlightenment = Well I did not play any game last 1700 so far but according to wikipedia reach dip tech 20 and hire natural scientist or build lots of univercities.
My Russia playthrough
Prussia is my march, riga and byzantium are my vassal. Don't go too much east until Printing Press. Technology is in west not in east. For monarch points you have a great disinherit button I once used 6 in row to get a good heir.My worst ruler got 11 mana + 3 from PP and advissors give 5-7 mana each month. I could start colonialism in moscow in 1500 with spare points I had. (ahead in all technologies)