None of the targets are really stronger in 1405 compared to 1399; some of them, notably the Ottomans, are far weaker. That's the whole point. The only potential problem that arises for a player in 1405 compared to 1399 is that the Timurids are much more likely to get involved with your later expansions into Anatolia, and they can be annoying opponents.
Now, the Ottomans also have a good chance of getting totally raped by the Timurids in the 1399 start, from which they're saved in 1405. And it is slightly more than five extra years.
I prefer to start i 1403 and always attack Epirus first, right after Naples attack them (remember to build units from the start of the game). Once the province i taken, I prepair to attack the ottomans at just the right moment, when it's big army goes to anatolia. Then I block the stait and take all i europe, cross the strait and get the rest. That way, the ottomans end up with only one province. Then I take the rest of the anatolian cores from the muslims. Now have the income to use spies, som I use them to take provinces like rhodes and cyprus. Always keep an eye what the big boys are doing, because they might not inter the war, if thay are already fighting another big one. In my current byz game, I got all core provinces by 1425. After this, I use missions to get kill of Naples, Venice, Sicily and Rome. Then I start taking Northen Italian provinces because of universitys and good income. In the proces, I weaken bohemia and often also Austria, so they dont get too big.