Whenever I play tall (though, granted, it's usually nowhere near as tall as Virtual enforces), I spend my time hyperoptimizing the planet layout and which pops are in which job, making sure the empire is carefully tuned to not over/underproduce anything at any point in development, handpicking governors for specific planets, checking for juicy colonization targets (like planets with special modifiers and lots of size), playing gotta-catch-em-all with leviathans and parade situations for modifiers, fiddling with politics to get the best GC resolutions passed (and make sure no others get advanced), integrating/fixing/rereleasing vassals, and other such shenanigans.
Having a huge empire keeps me so busy with claiming new systems, building up planets, making sure the Hegemonic Imperialist up galactic-north doesn't get too uppity because my fleets can't be in the north and south at the same time (and the southern one recently insulted the fact that I wear clothes), etc. that I don't have time to optimize anything, so the empire is half as efficient as it otherwise could be.
It's satisfying every once in a while to make things run like clockwork instead of it being barely managed chaos.