Roger that.
Still just under 100 years to go, I'm gonna try to solidify my hold on South England/North France, the Bosphorous Sound, Sinai, Rome, and the Baltic Sound (maybe). At this stage I'm so far ahead in tech and income that there really isn't going to be an 'end game boss', so unfortunately it looks like I'm just gonna have to coast on through to the end, which is unfortunate because for a while there Portugal (who got owned by Burgundy), Burgundy (who got owned by me), and Bohemia (who got owned by themselves) looked like they would be worthy foes; I even baited the Oirats into taking a nice line of provinces for me to perma-occupy to protect me and my vassals from Blobhemia. Was still a fun game; kicked the Europeans out of America and managed to keep my culture as the overwhelming majority (90%+), kept the Europeans out of East Russia / Oceania completely, and took all of the 'key locations' of Eurasia: An Indian trade port, Thrace, Cape Town, Singapore, Gibraltar, Dover + all the little islands in the Atlantic/Pacific/Indian Oceans (bar 3).
I'd take japan and call it a day