My current game with Aragon (5.1, just normal difficulty, no mods)
I just recently colonized the final province in South America, which could have happened a lot earlier if I hadn't dropped QftNW too soon. The next step will be to annex Savoy for Dauphine and Milan for Parma and then... I don't really know. Maybe I'll carve additional vassals out of the HRE and trim Bohemia some more... or maybe I'll just start a new game.