Adal has an alliance with Persia and is guaranteed by the Mamluks (that's why it's sometimes useful to release vassals, people). Other than that, no major powers will be involved, and the Mamluks and Persia stopped being “major” quite a while ago.
I will express the results of the war pictorially:
1529-31 sees a gold war with the Inca. I'm holding off on annexing them until I drain them dry.
In 1533, worried that the British - who are patrolling East Africa nonstop by this point - might beat me to the riches of Kongo, I declare war and take their maritime province (as well as a lot of gold) in the peace settlement. They are now cut off from the sea, and hopefully will remain for me to loot many a time in the future.
The same year brings a near disaster: Syria foolishly declares war on Iraq, bringing in half the Muslim world including the Ottomans. The AI doesn't seem to consider guarantees at all in declaring war. This is a problem for me because the Ottomans might take Aleppo and gain a direct border with me, resulting in war before I'm ready. Consequently, I declare war on Syria to keep the Ottomans out. The resulting peace treaty vassalizes them to avoid further shenanigans and takes one province, en route to my Persian possessions which I ultimately hope to link up to avoid future distant overseas penalties once I reach India and China.
1534 brings a wave of cores from the first Mamluk war, and al-Suriyah Arabic is accepted. These provinces are all converted, so the results are quite nice.
At this point I pause and rethink my strategy for the next few years.